About the job
We are seeking a highly motivated and experienced bioanalytical chemist focused on mass spectroscopy to join our PK, metabolism, and biomarker discovery group. This group focuses on liquid chromatography-mass spectrometry (LC-MS) based quantitation of small molecule drugs and metabolites and lipidomic studies to characterize and monitor disease states ex-vivo and in-vivo in support of drug discovery and enabling drug development by providing key information to drive the drug-discovery process.
The successful candidate will have skill sets in bioanalytical chemistry and LC-MS, as well as in biological sample handling and preparation. They will also be able to learn techniques quickly to support new project needs. The candidate should enjoy working in multi-disciplinary teams comprised of medicinal chemists, enzymologists, molecular cell, and chemical biologists and DMPK experts working to develop novel therapeutics. This role is a laboratory-oriented role with future growth potential.
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The best candidate for this role will have demonstrated success in these responsibilities:
• Conducting end-to-end analysis of LC-MS based PK, quantitative metabolomics and lipidomic studies to understand and monitor the modulation of ferroptosis sensitive cell state(s).
• Prior experience in lipidomics and/or metabolomics is required.
• Studying compound distribution and metabolism, PD biomarker responses, LC-MS, and data analysis on in vitro and in vivo samples to assess target modulation, and to identify biomarkers of target engagement and efficacy.
• Conducting metabolome and lipidome extraction from various biological matrices including cells, animal tissues, and biofluids using liquid, liquid-liquid multiphase and solid phase extraction techniques via metabolome and lipidome fractionation based on molecular properties.
• Performing regular upkeep and troubleshoot LCMS instrumentation as needed, including (U)HPLCs, Agilent single and triple quadrupole, Thermo Orbitraps, etc.
• Using both public and vender supplied mass spectrometry software for processing, analyzing, and annotating targeted & untargeted metabolomics/lipidomic data.
• Interpreting metabolomics/lipidomic data using various statistical & visualization tools. Communicating and presenting results to project teams.
• Sharing separations science expertise across drug discovery to drive process improvements.
The ideal candidate for this role will have the following qualifications:
• Ph.D. degree in chemistry, biochemistry, or a related field with 3-5 years of relevant industry experience.
• Hands-on experience in applied LC-MS and general analytical chemistry techniques.
• Capable of operating and troubleshooting one or more of the following LC-MS, LC-MS/MS instruments: (U)HPLC/triple quad LCMS (Agilent/SCIEX), Q-TOF, high resolution Accurate Mass Thermo Orbitrap series.
• Good knowledge in MS behavior of a given molecular structure and a deep understanding of molecular properties-based LC separations of metabolome and lipidome.
• Familiarity with major LC column types, separation mechanisms and applications.
• Self-driven/managed, adaptable, competent, and always fully engaged with what you do.
• Excellent verbal and written communication skills.
• Ability to work both independently and as part of a team.
• Demonstrated passion in bioanalytic science and determination for success.
• Possess a goal driven mindset for addressing scientific questions and being detail oriented.
• Be flexible and open to new technology and instrumentation applications in addition to MS
• Experience in proteomics and with metabolic isotopic tracer study concept and practice preferred.
About Us
Kojin Therapeutics, Inc. is harnessing groundbreaking discoveries in cell-state and ferroptosis biology to develop first-in-class, oral treatments for use in patients with various forms of cancer, as well as cardiovascular, immunologic, hepatic, and degenerative diseases. Named after the Japanese deity that tamed fire for the good of humanity, Kojin is located in Boston's Seaport biotech neighborhood. We have developed a drug-discovery platform that integrates computational chemistry, structural biology, chemical biology, target-informed screening, and mechanism-driven pharmacology to develop small-molecule therapeutics that specifically modulate ferroptosis -- a newly discovered form of programmed cell death. Kojin is backed by a strong syndicate of top-tier investors, led by an experienced biotechnology and pharmaceutical-industry leadership team, and driven by creative dedicated professionals.
We accept submission of CVs directly from candidates but not from any third-party recruitment or staffing agencies.
Featured benefits
• Medical insurance
• Commuter benefits
• Disability insurance
• Vision insurance
• Dental insurance
• 401(k)
• Paid maternity leave
• Paid paternity leave
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